Basics
Starting SolidMesh
Type in sm at the command line to invoke SolidMesh.  A list of the command line options is available here.  User-specified preferences may be set in the set-up file.
Hot Keys
Some of the more frequently used buttons in SolidMesh have an associated keyboard "hot key".  A list of the hot keys and their associated functionality can be found here.
The SolidMesh Window
 
The window consists of the drawing area, message area, group edit area, global picking area, global graphics edit area, application area, and application selection area. This may be more evident if you inspect the exploded view of the window.
The SolidMesh Window